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After that, (ii) we focused on the winning family considering the most significant modulation effect induced by our task. The selection of a model yields the exceedance probability for each model family/model, which express the probability (in %) that a particular family/model is more likely than any other. Exceedance probabilities for all families/models sum to 100%. RESULTS GLM GROUP ANALYSIS RESULTS Prior to conducting the DCM analyses described above, a conventional second-level Random Effect Analysis LDN-193189 in vivo (RFX) was conducted on the HRF for the whole brain volume (p 12) as to confirm the involvement of motor, premotor, and parietal regions in our task. The contrast of interest tested for specific effects of precision grip movements Etomidate performed with the RDH or with the LNH. These contrasts identified activation of cortical areas consisting of primary motor and premotor cortices, as well as parietal areas (see Table ?Table22). In particular, while activity associated with precision grip movements performed with the RDH appeared to be more circumscribed to the left contralateral hemisphere, activity observed for precision grip movements performed with the LNH involved dorsal premotor and parietal regions of both hemispheres. The group analysis did not reveal any significant activity in the left vPMC, which was observed by means of a small volume correction (Worsley et al., 1996) instead. As described in the ��VOI definition�� section, the VOIs were located for each participant following both functional and anatomical criteria. This procedure ensured that the functional regions included in the DCM models were C646 as consistent as possible across subjects (Stephan et al., 2007; Seghier et al., 2011). Coordinates for each single region in each participant are reported in Table 1 of the Supplementary Material. No significant effects were observed for the same analysis procedure conducted on the time derivative included in the GLM model. Table 2 Results of the RFX analysis performed on the whole group (p 12). DCM RESULTS Effective connectivity was tested by DCM-10, implemented in SPM8 toolbox (Wellcome Department of Imaging Neuroscience, London, UK), running under Matlab R2011a (The MathWorks, Natick, MA, USA). Family wise results Bayesian Model Selection was used first to decide which family model (RDH or LNH) better explains the measured data. The results showed that the ��LNH�� family had an exceedance probability of 0.8902 compared to the ��RDH�� family (0.1098; see Figure ?Figure3A3A). The winner family contains four models hypothesizing inter-hemispheric connections between homologs areas (AIP, vPMC, dPMC, and M1) as ��influenced�� by precision grip movements performed with the LNH, which assumes that the modulation of connections starts from the right hemisphere.