Staurosporine Information And Also Urban Myths

The trial was registered in clinicaltrials.gov (ID: NCT02088502). Sample size was calculated using the G*Power software (version 3.1.7, Universit?t Kiel, Germany). Considering the effect size of 0.3,11 significance level of 0.05, and study power of 0.8, a total sample of 32 patients in each group was required. Patients in the theophylline group received200 mg slow-release theophylline tablet (Darupakhsh Co., Tehran, Dorsomorphin Iran) plus placebo, and patients in the N-acetylcysteine group received600 mg non-effervescent N-acetylcysteine tablet (Shafa Co., Tehran, Iran) plus placebo, twice daily, from 24 h before to 48 h after administration of contrast material. Patients in theophylline plus N-acetylcysteine group received both drugs in the same order. All patients were hydrated with 0.9% sodium chloride (1 ml/kg/h) for 24 h, started 12 h before operation. Patients with left-ventricular ejection fraction of less than 40% or New York Heart Association functional class of III-IV were hydrated at rate of 0.5 ml/kg/h. Angiography �� angioplasty was done according to the clinical standards, by trans-femoral or trans-radial approach. In all cases, Iodixanol (Visipaque?, Amersham Healthcare, Cork, Ireland) was used as a non-ionic contrast media with low contrast osmolality. Before the operation, all the patients underwent a detailed history and physical examination by a cardiologist. Staurosporine datasheet Age, gender, and history of hypertension, diabetes mellitus, dyslipidemia, and smoking were recorded, and weight Resminostat was measured. Cardiopulmonary examination was done for the evaluation of heart failure and systolic/diastolic blood pressure. Complete blood count was checked for anemia before operation. The volume of contrast material used was recorded for each patient. Serum creatinine was measured before and 48 h after contrast material injection in a hospital laboratory and the amount of change was considered as the study outcome. CIN was defined as an increase in serum creatinine level of �� 0.5 mg/dl or �� 25% of the baseline creatinine after 48 h of contrast material injection.18 Data were analyzed using the SPSS software for Windows (version 16.0, SPSS Inc., Chicago, IL, USA). Data are presented as mean �� standard deviation or number (%). The chi-square test was applied for comparison of qualitative data between groups. Quantitative data were checked if normally distributed in each group using the Kolmogorov-Smirnov Test. If data were normally distributed, the ANOVA test (with Tukey post-hoc) was applied for comparisons among the three study groups. If data was not normally distributed, the Kruskal-Wallis test was applied, followed by the Mann-Whitney U-test for comparisons between each two pairs. The Wilcoxon test was applied for within-group comparisons. Furthermore, the ANCOVA test was done for controlling the effects of covariates. P