Cloth59butter : Page créée avec « ""2790" "Transmyocardial laser revascularization (TMR) is currently clinically performed with either a CO2 or Ho:YAG laser for the treatment of severe angina. While both l... »

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Page créée avec « ""2790" "Transmyocardial laser revascularization (TMR) is currently clinically performed with either a CO2 or Ho:YAG laser for the treatment of severe angina. While both l... »

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""2790" "Transmyocardial laser revascularization (TMR) is currently clinically performed with either a CO2 or Ho:YAG laser for the treatment of severe angina. While both lasers provide symptomatic relief, there are significant differences in the laser�Ctissue interactions specific to each device that may impact their ability to enhance the perfusion of myocardium and thereby improve contractile function of the ischemic heart. A porcine model of chronic myocardial ischemia was employed. After collecting baseline functional data with cine magnetic resonance imaging (MRI) and dobutamine [http://www.selleckchem.com/products/scr7.html SCR7 in vitro] stress echo (DSE), 14 animals underwent TMR with either a CO2 or Ho:YAG laser. Transmural channels were created with each laser in a distribution of 1/cm2 in the ischemic zone. Six weeks post-treatment repeat MRI as well as DSE were obtained after which the animals were sacrificed. Histology was preformed to characterize the laser�Ctissue interaction. CO2 TMR led to improvement in wall thickening in the ischemic area as seen with cine MRI (40.3% vs. baseline, P?[http://en.wikipedia.org/wiki/Mianserin Mianserin HCl] In a side-by-side comparison CO2 TMR resulted in improved function of ischemic myocardium as assessed by MRI and echocardiography. Ho:YAG TMR led to no improvement [http://www.selleckchem.com/products/MS-275.html selleck chemical] in regional function likely due to concomitant increase in fibrosis in the lasered area. Lasers Surg. Med. 42:906�C911, 2010. ? 2010 Wiley-Liss, Inc. ""2791" "Background? Human African trypanosomiasis is associated with metabolic changes which have not been well characterized. Methods?Chlorocebus aethiops were experimentally infected with Trypanosoma brucei rhodesiense and late-stage disease induced at 28?days post-infection. Ear prick blood for glucose determination and blood samples were obtained at weekly intervals for 56?days. Analysis was carried out using dry chemistry analysis. Results? In early infection, there was a significant increase in creatine kinase, while during early and transitional stage of infection there was a significant decrease in glucose and high-density lipoprotein and an increase in triglyceride levels. In the late stage, there was a significant increase in both total cholesterol and LDL levels. Conclusions? Further investigations should focus on levels of total cholesterol during the follow-up period in curatively treated vervet monkeys. Apart from their importance in disease staging, the changes in lipids levels may also affect the pharmacokinetics of some trypanocides.

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Cloth59butter : Page créée avec « ""2790" "Transmyocardial laser revascularization (TMR) is currently clinically performed with either a CO2 or Ho:YAG laser for the treatment of severe angina. While both l... »