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In the multivariate analysis, a less favourable clinical response was associated with female gender (HR, 0.53; 95% CI, 0.36�C0.79), baseline symptoms score >14 (HR, 0.47; 0.32�C0.70), baseline normalized viral load ��5?log cgeq/��L (HR, 0.63; 0.43�C0.93), and initiation of antibiotics at baseline (HR, 0.30; 0.12�C0.76) (Table?2). Figure?1 presents the time to alleviation of symptoms in the 141 patients treated with oseltamivir according to sex and days 0�C2 compliance. For zanamivir, in univariate analysis, explanatory variables with p-values 14 and presence of physical signs (Table?2). In the multivariate analysis, the clinical response was not associated with any explanatory variable (Table?2). For oseltamivir, in univariate analysis, explanatory variables with p-values [http://en.wikipedia.org/wiki/Transducin Transducin] viral load ��5?log cgeq/��L and compliance between day 0 and day [http://www.selleckchem.com/products/Staurosporine.html learn more] 2 (Table?3). In the multivariate analysis, a less favourable virological response was associated with female gender (OR, 0.45; 0.21�C0.96), baseline normalized viral load ��5?log cgeq/��L (OR, 0.40; 0.20�C0.84) and days 0�C2 incomplete compliance (OR, 0.31; 0.10�C0.98) (Table?3). For zanamivir, in univariate analysis, explanatory variables with p-values [http://www.selleckchem.com/products/gsk126.html GSK126 datasheet] was associated with an initiation of antibiotics at baseline (OR, 4.24; 1.07�C17.50) (Table?3). In the present study, various factors appeared to be associated with the clinical and/or virological responses to neuraminidase inhibitors in the context of the 2008/2009 seasonal influenza, mainly due to H3N2 viruses. Most were clinically relevant data such as: gender, age, baseline score of symptoms, prescription of antibiotics, and compliance. One item of virologically relevant information, nasal viral load at baseline, appears to be independently associated with the response. Different associations of these factors were found depending on the antiviral drug and on whether the clinical or virological response was considered. Three types of factors were associated with either the clinical or the virological response to oseltamivir: compliance, gender and intensity of the disease, none of these having been previously reported in the literature, possibly because they were not tested. It is a hypothesis that the particular context of a therapeutic trial, with systematic recording of detailed clinical and virological data, may have favoured their detection.

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Butane3area : Page créée avec « In the multivariate analysis, a less favourable clinical response was associated with female gender (HR, 0.53; 95% CI, 0.36�C0.79), baseline symptoms score >14 (HR, 0.47... »