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<p>Page créée avec « [30] Cytotoxic activity of 1 Oppositifolone 1 was evaluated for cytotoxicity against the human cancer cell lines, nonsmall cell lung adenocarcinoma (A549) and HCT 116, and... »</p> <p><b>Nouvelle page</b></p><div>[30] Cytotoxic activity of 1 Oppositifolone 1 was evaluated for cytotoxicity against the human cancer cell lines, nonsmall cell lung adenocarcinoma (A549) and HCT 116, and the noncancer cell line Chinese hamster ovary cells (AA8) using the MTT cytotoxicity assay. Triterpene 1 was cytotoxic against HCT 116 with IC50 value of 28.7 ��g/ml, while Doxorubicin exhibited an IC50 value of 1.9 ��g/ml [Figure 2]. Triterpene 1 and Doxorubicin were also cytotoxic against AA8 with IC50 values of 37.5 ��g/ml and 2.3 ��g/ml, respectively. Triterpene 1 had no linear interpolation with the A549, thus, IC50 could not be calculated. This implied that 1 did not exhibit cytotoxic effect against this cell line. Figure 2 IC50 value of 1 and Doxorubicin against a human cancer cell [http://www.selleckchem.com/Akt.html Akt inhibitor] line colon carcinoma 116 and a noncancer cell line Chinese hamster ovary cells (AA8) Hypoglycemic activity The hypoglycemic potential of 1, DCM and aqueous leaf [http://en.wikipedia.org/wiki/Montelukast Montelukast Sodium] extracts were observed in groups of mice administered with the test samples, positive control (Solosa), and negative controls (polysorbate 80 and water) within a 3 h blood glucose measurement period at 0.5 h intervals. The percent blood glucose reductions of aqueous leaf extracts at 25, 50, 100, and 200 mg/kg BW taken within a 3 h blood glucose measurement period at 0.5 h intervals are presented in Figure ?Figure3a3a-?-e.e. Solosa was observed to be a fast acting hypoglycemic agent with a relatively short duration of activity. Solosa was able to reduce blood glucose levels at an average rate of 62.27 �� 16.8% for the first 0.5 h of measurement [Figure 3a] and 29.46% ��17.4% for the 1st h of measurement [Figure 3b]. Such a percentage reduction is concomitant with the reported physiological effects of Solosa on blood glucose reduction.[31] At 0.5 h, the positive control (Solosa) is significantly different (P [http://www.selleckchem.com/products/epz-6438.html EPZ-6438 nmr] activity similar to the positive control [Figure 3a]. In the next 1 h and 1.5 h, the blood glucose reduction may be due to insulin since the % reduction for the aqueous leaf extract and the negative control (water) are similar [Figure ?[Figure3b3b and ?andcc]. Figure 3 (a) Percent blood glucose reduction of aqueous extract at 25, 50, 100, and 200 mg/kg body weight taken at 0.5 h (b) Percent blood glucose reduction of aqueous extract at 25, 50, 100, and 200 mg/kg body weight taken at 1 h (c) Percent blood glucose reduction ...</div>

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