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<p>Page créée avec « 0/1,000 patient-years) as compared to IS drugs (13.6/1000 patient-years; P treated in outpatient settings and those treated without formal medical intervention. Furthermor... »</p> <p><b>Nouvelle page</b></p><div>0/1,000 patient-years) as compared to IS drugs (13.6/1000 patient-years; P treated in outpatient settings and those treated without formal medical intervention. Furthermore, patients treated in hospital but coded with diagnoses such as syncope or fall and not including hypoglycemia were missed. Thus, the estimated rates of severe hypoglycemic episodes in the present EGB analysis were quite conservative in all cohorts. For this reason, it was of interest to complement our main analysis with data, certainly less robust and [http://www.selleckchem.com/products/byl719.html BYL719 price] subject to declaration bias, but nevertheless covering a wider range of hypoglycemic events, collected by GP interviews at routine patients�� visits in the concomitant HYPOVI panel. All hypoglycemic episodes that patients recalled at the visit were reported, [https://en.wikipedia.org/wiki/Pramipexole Pramipexole] whatever the consequences. More severe events were more likely to be reported accurately with less memory bias, particularly those that had led to hospitalization. It is remarkable in this regard that the adjusted estimates of hypoglycemia leading to hospitalization were almost identical to those derived from the EGB database (0.0/1,000 patient-years [95% CI: 0.0; 47.7] with vildagliptin versus 13.2/1,000 patient-years [95% CI: 3.6; 33.8] with IS; P=0.3958). Adjusted rates of the more common hypoglycemia (all events) were also markedly reduced with vildagliptin relative to IS (63.3/1,000 patient-years [95% CI: 7.8; 118.8] versus 168.3/1,000 patient-years [95% CI: 122.1; 214.5]; P=0.0214). The possibilities to adjust for potential confounding factors were limited by the unavailability of some important variables in the EGB, such as glycemic control. Indeed, when comparing rates of hypoglycemia, is it important to take into [http://www.selleckchem.com/products/Bosutinib.html SKI-606 clinical trial] account the level of glucose control.22 In this regard, data from HYPOVI during the same period were reassuring in showing that a cohort of patients treated with IS did not have tighter levels of glucose control than patients treated with vildagliptin (mean HbA1c of 7.3% and 43.9% of patients with HbA1c</div>

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