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Effect on swelling was measured with measuring tape. The glomerular filtration rate (GFR) was measured using Cockcroft-Gault equation: Multiply by 0.85 for women.[15] All patients were assessed for general condition at 15 days interval until 48th day of the treatment. Later follow-up for 2 months. GFR - Grading was done [http://en.wikipedia.org/wiki/Megestrol_acetate Megestrol Acetate] from 0 to 3.[16] GFR is not a significant indicator of glomerular damage in early stages of DN. Microalbuminuria is a better indicator for progression and also to decide the prognosis of renal disease in earlier stages.[17] Efficacy and safety parameters Efficacy variable The efficacy variables were subjective parameters like Akshikoota shotha (retro orbital oedema), Pada Shotha (pedal edema), Dourbalyata (fatigue), Agnimandhya (loss of appetite), and objective parameters like microalbuminuria, serum albumin, serum creatinine, GFR, blood urea and albuminuria (AL), blood pressure and FBS and PPBS. Safety variable Any side-effects as experienced by the patient or observed by the investigator during the course of [http://www.selleckchem.com/products/Gemcitabine-Hydrochloride(Gemzar).html Selleckchem Gemcitabine] treatment with the study drug were recorded in case record form. Criteria of assessment Glomerular filtration rate Criteria: Score Severe: 125 mL/min/1.73 m2-1 Normal: 125 mL/min/1.73 m2-0. Albuminuria Criteria: Score Severe: 125 mL/min/1.73 m2-1 Normal: 125 mL/min/1.73 m2-0. Microalbuminuria (24 h) Criteria: Score Abnormal: >200 ��g/min% - 3 Moderate: 100�C200 ��g/min% - 2 Mild: >30�C100 ��g/min% - 1 Normal: [http://www.selleckchem.com/products/birinapant-tl32711.html learn more] (retro orbital oedema) Criteria: Score Severe: 3 Moderate: 2 Mild: 1 Normal: 0. Statistical analysis Assessment of the patients was done before the treatment, after 15, 30 and 48th day the treatment. The data were collected and analyzed, the total score of before treatment, during and after treatment was assessed using students paired t-test, descriptive statistics and contingency coefficient. Analysis was done through SPSS (Statistical Presentation System Software) for Windows, version 14.0, evaluation version (SPSS, 2005, SPSS Inc., New York, NY, USA). Observations Most of the patients (66.7%) were of 60�C80 years of age, followed by 20�C40 years of age (20%) found prone to DN. Out of total 15 patients 9 (60%) were males and 6 (40%) were females. In study type 1 diabetic patients outnumbered type 2 diabetics (60% vs. 40%), maximum number of patients (10 i.e. 66.7%) showed familial inheritance of DM, 53.3% patients developed DN after 1�C10 years duration of diabetes 86.7% had association of HTN along with DM. Maximum number of patients that is, 10 (66.7%) of them had mild nonproliferative diabetic retinopathy (NPDR), 4 (26.7%) had moderate NPDR.