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Clinical parameters recorded included plaque index, gingival index, probing pocket depth and clinical attachment loss. The medical questionnaire collected information on family history of stroke, dietary history, history of smoking and history of alcohol consumption. Cases were additionally scrutinized for diabetes, hypertension and total serum cholesterol level. The education level of patients was also considered. Results:? The mean plaque index, gingival index, probing pocket depth and clinical attachment loss values of subjects with cerebrovascular accident were significantly higher when compared with those of the control group (p??4.5?mm was found to be the most significant factor for stroke (odds ratio?=?8.5; confidence interval?=?1.1�C68.2) followed by hypertension (odds [http://en.wikipedia.org/wiki/Unoprostone Unoprostone] ratio?=?7.6; confidence interval?=?3.3�C17.1) and smoking (odds ratio?=?3.1; confidence interval?=?1.3�C7.4). Conclusion:? The data from this study support the proposed link between periodontitis and cerebrovascular accident in the Indian population. However, further studies are necessary to verify and quantify the role of oral infections and genetic factors in the process of atherosclerosis. ""Periodontitis is becoming a highly prevalent [http://www.selleckchem.com/products/bgj398-nvp-bgj398.html BGJ398] disease worldwide. Obstructive sleep apnea (OSA) is a common disorder that is characterized by repeated disruptions in breathing during sleep, and mouth breathing is a common characteristic among patients with OSA. We aimed to assess the hypothesis that OSA is associated with the onset and progression of periodontal disease. This is a cross-sectional study of a total of 687 participants (460 men and 227 women), 47�C77?years of age, who were examined between August [http://www.selleckchem.com/screening/protease-inhibitor-library.html Selleck Protease Inhibitor Library] 2009 and September 2010 as part of the Korean Genome and Epidemiology Study. The participants underwent standard polysomnography, clinical periodontal examination and health-screening examinations. Periodontitis was defined as clinical attachment level (CAL) ��?6?mm and probing pocket depth ��?4?mm. OSA was determined using the apnea�Chypopnea index (AHI), and an AHI score of ��?5 was the cut-off used to indicate the presence of OSA. The results showed that 17.5% of the participants had periodontitis, 46.6% had OSA and 60.0% who were diagnosed with periodontitis had OSA. In our study, old age, male gender, current smoking status, mouth breathing during sleep and high AHI were identified as risk factors for periodontitis. OSA was positively associated with periodontitis [odds ratio (OR)?=?1.84, 95% confidence interval (CI)?=?1.18�C2.87], probing pocket depth (OR?=?2.22, 95% CI?=?1.30�C3.77) and CAL (OR?=?1.86, 95% CI?=?1.07�C3.21) in a dose�Cresponse manner. Additionally, OSA was positively associated with periodontitis (OR?=?2.51, 95% CI?=?1.37�C4.62) in subjects ��?55?years of age, but not in subjects