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The findings can be used to determine the core clinical educational content of general medicine, to make decisions as for the probable revision necessary in general medicine curriculum and also to revise the continued education programs of physicians working in urban and rural centers. SUBJECTS AND METHODS This cross-sectional descriptive study was done throughout Isfahan province in 2011. The population included general practitioners in rural and urban health care centers in Isfahan province; they all were 1906 physicians. Entry criterion was working experience of over 1 year and [https://en.wikipedia.org/wiki/E-64 E-64] the province and through cluster sampling. Isfahan province was divided to 5 clusters; 20 samples of each cluster was selected using simple randomized method. To gather data, a set of questionnaires were prepared. The first section of the questionnaires included demographic information; the second section covered titles of gynecological/obstetric and pediatric diseases determined separately using medical education content of diseases of [http://www.selleckchem.com/products/jq1.html JQ1 cost] major wards from Shahid Beheshti University study and later revised by the scientific faculty members of Isfahan University. In all, in the two questionnaires [Questionnaires 1 and 2], there were 134 cases of pediatric diseases and 122 cases of gynecological/obstetric diseases. Validity of the questionnaires for each category of diseases was examined by 2 specialists of the relevant field, 4 general practitioners and 3 graduates in medical education. The frequency of encounter with the symptoms and diseases in question were specified according to 5-point Likert scale including rare, sometimes, weekly to monthly, daily to weekly and daily items. The items were allocated the marks 1, 2, 3, 4 and 5, respectively. In the pilot study, the reliability of the questionnaire was examined on 10% of the whole sample (Cronbach's alpha = 93%). A total of 100 questionnaires were distributed in the first half of 2011 by post (and after a phone call and agreement of the physician) or, in some cities, by help from continuing medical education staff. A set of gifts were taken into account in order to encourage participation. 64 out of 100 questionnaires completed [http://www.selleckchem.com/products/r428.html learn more] and returned within a month. The data were analyzed by SPSS 11.5. The average score for a symptom or disease was taken as the criterion for the encounter rate of that symptom or disease. Thus, the average mark 5, for example, indicated the maximum encounter rate while the average mark 1 showed the minimum rate. RESULTS A total of 28 male and 36 female physicians completed the questionnaires. Demographic characteristics of participants and their workplace are mentioned in Table 1.