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The concentrations of allergens were 10 HEP (Soluprick SQ system; ALK Albell��, Hoersholm, Denmark). Reactions were read after 15?min. A positive result (atopy) was defined as a positive reaction to at least one of the allergens, and a reaction was considered positive if the mean wheal diameter was at least 3?mm. The participants were requested to discontinue medications that contained antihistamines at least 3?days before skin testing. Subjects with asthma concomitantly with a positive [http://www.selleckchem.com/products/ag-221-enasidenib.html this website] skin prick test were regarded atopic (16). The data were analysed with the statistical package spss 17.0 (SPSS Inc., Chicago, IL, USA) for Windows. Differences in proportions were tested with a Chi-square test, whereas differences in continuous variables were analysed with anova, and in case of significance, the differences in characteristics according to the three groups were analysed by an unpaired t-test. In cases of skewed variables, non-parametric analysis was used. The mean (SD) age was 29 (9) years with no differences between the three groups (Table?1). Men more often had rhinitis as single disease, whereas women had a higher frequency of asthma (P?[https://en.wikipedia.org/wiki/Succimer Succimer] the GINA guidelines, the participating asthmatics in general had persistent symptoms (59%), and those with both asthma and rhinitis seemed to have less severe asthma compared to those with asthma alone (55.1%vs 66.3%P?[http://www.selleckchem.com/products/rsl3.html www.selleckchem.com/products/rsl3.html] who had asthma only (48.6% and 39.3%, respectively, P?