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The P/E ratio for female patients born abroad was 0.9 and for male patients 1.4; for patients born in Sweden the ratios were 1.8 and 4.0, respectively. Pulmonary TB was also more common in elderly patients (P/E ratio 1.7 for those ��65?years). When clinical manifestations of disease were analysed in relation to origin and age, the P/E ratio among Swedish patients [http://www.selleckchem.com/products/Bafilomycin-A1.html http://www.selleckchem.com/products/Bafilomycin-A1.html] indicating that the former population was more inclined to develop pulmonary TB. Pulmonary TB was more common among patients originating in Europe (P/E ratio 2.7), Sweden (P/E ratio 2.9) and South America (P/E ratio 7.0), though the number of patients from South America was too low to be conclusive (Table?2, Fig.?1b). Extrapulmonary manifestations of TB were significantly more common in patients born in Africa (P/E ratio 0.7, OR 3.3, p?[https://en.wikipedia.org/wiki/Phosphoprotein_phosphatase Phosphoprotein phosphatase] in patients born in the Middle East than the reference group, including patients born in Europe (including Sweden) and South America. Using genotyping, 313/349 (90%) isolates were classified among 10 lineages while 36 (10%) were unclassified. Six large lineages (total 297 isolates) are illustrated in Table?2, the remaining 52 are together designated ��Other��. Statistical analysis indicated [http://www.selleckchem.com/products/pf-06463922.html PF-06463922 ic50] an increased risk of extrapulmonary TB in patients infected by the EAI lineage (OR 3.0, p 0.012) and CAS family (OR 2.4, p 0.047; Table?2, Fig.?1b). In contrast, lung TB without extrapulmonary manifestations dominated among the patients infected with the Beijing and T lineages (adjusted OR of 4.44, 95% CI 1.13�C17.54, p 0.033 for pulmonary TB; Table?2). The proportion of extrapulmonary vs. pulmonary TB in relation to genotyping data and the geographical origin of the patients underlined that the distribution of genotypes observed was dependent on the origin of the patients (Fig.?1b, Table?3). T clade was most common in patients born in Sweden (31/89, 35%), Europe (23/59, 39%) and Africa (29/98, 30%); Haarlem lineage was relatively common in the Middle East (14/40, 35%) but rare in Africa (5/98, 5%); EAI was common in Africa (23/98, 23.5%) and Asia (19/55, 34.5%); CAS was equally common in Africa (20/98, 20%) and Asia (10/55, 18%), and also present to a lesser extent in the Middle-East (4/40, 10%); Beijing (W) was most commonly found in Asian-born patients (16/55, 29%). Certain lineages caused more extrapulmonary TB, while other lineages dominated in lung TB cases.