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Although, compared with Caucasian or African counterparts, [http://www.selleckchem.com/screening/protease-inhibitor-library.html Protease Inhibitor Library manufacturer] East Asians have distinct characteristics in glucose metabolism with higher insulin sensitivity and lower insulin secretory capacity across all glucose tolerance categories encompassing NGT, IFG/IGT, and type 2 diabetes [15], the clinical significance of the NGT 1 hour-high status has not yet been explored. Therefore, we compared metabolic characteristics of NGT 1 hour-high, NGT 1 hour-low, and IGT in Korean populations. METHODS The study protocol was approved by the Institutional Review Board at Seoul National University Hospital (registration number: H-1402-006-557). We recruited subjects aged 30 to 80 years by local advertisement. Subjects taking medications for diabetes, hypertension, hyperlipidemia, or obesity as well as pregnant women were excluded. Of the 280 subjects who were screened by means of the standard 75 g OGTT, 192 subjects with NGT, and 52 subjects with IGT were finally included in this study. For the OGTTs, subjects were asked to fast overnight. First, height, body weight, waist and hip circumferences, and systolic and diastolic blood pressures were measured. Then, fasting blood samples were drawn for the measurement of plasma concentrations of glucose, hemoglobin A1c, [http://en.wikipedia.org/wiki/Unoprostone Unoprostone] insulin, C-peptide, total cholesterol, triglyceride, low density lipoprotein cholesterol (LDL-C), and high density lipoprotein cholesterol (HDL-C). After a 75 g oral glucose load, blood samples were drawn at 30, 60, 90, and 120 minutes to measure [http://www.selleckchem.com/products/bgj398-nvp-bgj398.html BGJ398 molecular weight] plasma levels of glucose and insulin. Informed consent was obtained from all participants prior to any research procedures. According to 1-hour postload plasma glucose levels, the subjects with NGT were divided into the following two groups: 149 subjects with NGT 1 hour-low (